The Mono-Methyl-Histone H2B (Lys5) antibody from MyBioSource.com is a Rabbit Polyclonal antibody to H2B clustered histone 14, and H2BC14. This antibody recognizes Human antigen. The Mono-Methyl-Histone H2B (Lys5) antibody has been validated for the following applications: Western Blot.
Description
Rabbit anti Human mono-methyl-histone H2B (Lys5) antibody recognizes histone H2B when mono-methylated at lysine 5.
Histone H2B is one of the four core histones that make up the nucleosome core particle. Nucleosomes are the smallest subunit of chromatin and are made up of 146 bp of DNA wrapped around an octamer comprised of pairs of the four core histones (H2A, H2B, H3, and H4) (Smith, 1991). The presence of post-translational modifications and specialized variants of histone H2B helps the regulation of chromatin structure and function (Molden et al. 2015). It has been suggested that changes in methylation of histone H2B may be involved in heat-shock mechanisms. Mono-methylation of lysine 5 is thought to occur at active promoters downstream of the transcription start sight (Wozniak and Strahl, 2014).
Wide species cross-reactivity is expected from Rabbit anti Human mono-methyl-histone H2B (Lys5) antibody based on sequence